Work to install more than 600 metres of median safety barriers along a stretch of Picton Road at Cordeaux will begin this week.
A Roads and Maritime Services spokeman said the NSW Government had provided $1.3 million to improve safety along the notorious road with funding from the Safer Roads Program.
"This important safety work will help reduce the likelihood of head-on crashes at this location, which has a poor crash history," he said.
"In the five years to June 2018 preliminary data shows there were five crashes recorded within the project area."
The section of road to be upgraded is between 1.3 kilometres and 2.2 kilometres west of the Cordeaux Colliery entrance.
The spokesman said the existing 2.2 kilometre westbound overtaking lane will also be slightly reduced by about 500 metres in length, ending just before the curve, to provide sufficient room for the safety improvements to be carried out.
"Traffic will merge on a straight section of road where they have improved visibility, which is another positive safety outcome," he said.
"Other work being carried out at this location will include widening the centre lines and the westbound road shoulder, and road resurfacing."
Night work will be carried out from Sunday to Thursday between 7pm and 5am from May 23 to June 21, weather permitting.
No work will be carried out over the June long weekend.
Changes to the overtaking lane will be in place from May 24.
Changed traffic conditions including a reduced speed limit of 40 km/h, lane closures and stop/go traffic control will be in place during work hours for the safety of workers and motorists.
Speed limit outside work hours will be reduced to 80 km/h.
Motorists are advised to allow additional travel time and follow the directions of signs and traffic control.